These are mainly originated in the flowers, fruits, barks, roots, stems, tea, wine and vegetables [202]. Landscaping Features . It is hardy to zone (UK) 7. Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. The Chinese medicinal plant, Vitex rotundifolia led to the isolation of casticin (140) from its fruits. The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. The medicinal parts used are the dried leaves and fruits, although the red-black berry is used too. Uses, Benefits, Cures, Side Effects, Nutrients in Vitex Trifolia. Medicinal Uses of Vitex negundo. A series of nine geranylated flavones (160–168) namely 3′,4′-O-dimethyl-5′-hydroxydiplacone (160), tomentone (161), mimulone (162), 3′-O-methyl-5′-methoxy-diplacone (163), diplacone (164), geranylchromone (165), paulownione C (166), 3′-O-methyl-5′-hydroxydiplacone (167) and tomentodiplacone O (168) isolated from the fruits of Paulownia tomentosa and studied for their anti-inflammatory action and possible mechanism of action. Medicinal Plants Medicinal plants and their uses (medicinal herbs) Home » Medicinal and Aromatic Plants » Round Leaf Chastetree, Beach Vitex. Two flavan-3-ol-dihydroretrochalcone type dimers, dragonins A-B (183–184) were isolated from the resin of Daemonorops draco. Justicidin B (21), which is isolated as the major component of Phyllanthus piscatorum, inhibited the growth of Candida albicans (MIC = 4 μg/mL).118 Vitrofolal C, D (22, 23) and detetrahydroconidendrin (24), which belong to the phenylnaphthalene type lignans from Vitex rotundifolia, have been found to act against methicillin-resistant Staphylococcus aureus (MRSA) (MIC > 64 μg/mL).119 A hydrobenzofuranoide lignan, Heyneanol A (25), isolated from the root extract of Vitis sp., has showed antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes, and MRSA (MIC = 2, 4, 2 μg/mL).120,121. by Sunil and co-works in 1984.2 In 2001, Zhao and coworkers obtained dendroflorin (1) from D. densiflorum and revised its structure.3 A structural related nobilone (2) was isolated from 60% ethanol extract of the stems of Dendrobium nobile by Yao and coworkers in 2006.4 Both 1 and 2 displayed higher antioxidant activity than vitamin C in the ORAC assay, while dendroflorin (1) have a good performance in antioxidant activity higher than or equivalent to vitamin C in the DPPH assay. Additionally, care must be taken to avoid secondary infestations from other invasive plants such as Similax sp following BV removal. Man Jing Zi is also known as Vitex Fruit or Fructus Viticis and is the mature fruit of Vitex trifolia or Vitex rotundifolia. Additionally, compounds 121, 129 and 135 expressively suppressed LPS-induced expression of COX-2 protein [206]. beach vitex for use in the treatment of cancer (Haı¨dara et al. II. Navneet Kishore, ... Akhilesh Kumar Verma, in European Journal of Medicinal Chemistry, 2019. Vitex rotundifolia L. f. – roundleaf chastetree Subordinate Taxa. 55 A review of the important chemical constituents and medicinal uses of Vitex genus / Asian Journal of Traditional Medicines, 2011, 6 (2) negundo has larvicidal activity against the mosquito species Culex quinquefasciatus and Anopheles stephensi and is used as a mosquito deterrent againt Aedes aegypti and Vitex rotundifolia also acts as deterrent against Aedes aegypti. Medicinal use of Horse Brier: The stem prickles have been rubbed on the skin as a counter-irritant to relieve localised pains, muscle cramps and twitching. Qiaoyan Zhang. National Germplasm Resources Laboratory, Beltsville, Maryland. Azafluorenone has a similar structure as fluorenone with exception of a nitrogen in the skeleton. Epub 2018 Oct 11. Description. Similarly, compound 182 exhibited excellent COX-2 inhibitory activity with the IC50 value of 9.5 μM [217]. A suckling murine model was used to study the anticryptosporidial efficacies of both the drug and the inclusion complex with β-cyclodextrin (β-CD). Species trifolia means with three leaflets. Small aromatic medicinal spp. All the compounds displayed significant inhibition of LPS-induced NO production in microglial cells with the IC50 valuses of 18.0 (177), 7.0 (178), 19.7 (179) and 6.7 μM (180), respectively [216]. One of the objectives of WHO monographs is to provide a model that will support countries in developing their own na-tional or regional monographs on medicinal plants or national formular-ies on herbal medicines. & A.L. 6619 of the Clemson University Experiment Station. Rightfully so. Also known as chaste tree or chasteberry, it's often taken as a remedy for women's health problems. All compounds significantly decrease IL-1β levels in similar patterns detected in case of IL-6 levels at a concentration of 1 mM [212]. This plant has no children Legal Status. Control efforts are presently underway to protect the fragile beach dune ecosystem. In Verbenaceae (Burkill 1966:Vol. Interim Director, Coastal Research and Education Center, Clemson University, Clemson, SC 29632. Vitex trifolia and Vitex rotundifolia are deciduous shrubs, which belong to the Verbenaceae family. Medicinal studies have indicated the potential of BV for cancer therapy. Vitex supplements typically contain extracts of the fruit and/or seed of the plant. Components. Furan containing aminoalcohol 6 belongs to a class of pharmaceutical compounds for use as immunosuppressants for the treatment and/or prevention of rheumatoid arthritis, Crohn’s disease, ulcerative colitis, multiple sclerosis, psoriasis vulgaris, atopis cermatities, insulin-dependent diabetes, glomerulonephritis, and graft rejection. Add to Likebox #65717562 - A bumble bee close up on a purple vitex tree flower making pollen. Related Links. 2006), female hormone-related health issues (Hu et al. Vitex may influence hormone levels in a number of ways. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL:, URL:, URL:, URL:, URL:, Methicillin-Resistant Staphylococcus Aureus, Lead Compounds from Medicinal Plants for the Treatment of Cancer, Natural Products as Source of New Antimicrobial Compounds for Skin Infections, The Microbiology of Skin, Soft Tissue, Bone and Joint Infections, Five-membered Rings with One Heteroatom together with their Benzo and other Carbocyclic-fused Derivatives, Recent advances of synthesis of fluorenone and fluorene containing natural products, Human disorders associated with inflammation and the evolving role of natural products to overcome, Navneet Kishore, ... Akhilesh Kumar Verma, in. Add to Likebox #72156409 - Prescribed medicinal Vitex negundo as herbal medicine over white. Medicinal Plants in Papua New Guinea Publication Author Publisher World Health Organisation Year 2009 ISBN 978-92-9061-249-0 Description Traditional medicinal uses of 126 species from Papua New Guinea, including information on any modern research into the plants. Both the compounds showed COX-1, COX-2 and 5-LOX inhibitory activity greater than the standard use. Generally homeopathic medicines have a wide range of possible uses, and it is often considered on a person-by-person basis. The inhibition of COX-2 expression in the epidermal keratinocytes of PM-treated mice also proved in In vivo studies by the current treatment with eupafolin [209]. Association between chemical and genetic variation of Vitex rotundifolia populations from different locations in China: its implication for quality control of medicinal plants Yuan Hu. In China the plant is used to treat asthma. A mature Vitex rotundifolia produces fragrant, blue-purple flowers that are borne in clusters and ultimately yield small purblish-black fruits. The stem bark of Calpocalyx dinklagei afforded four (136–139) flavonoid derivatives namely, atalantoflavone (136), 8-prenylapigenin (137), 40,5,7-trihydroxy-2′-methoxyflavone (138) and morusin (139) form methanol extraction. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Vitex ovata Thunb., Vitex ovata var. The present review aims to compile medicinal values of Vitex … Vitex agnus-castus L. (Lamiaceae) is a medicinal plant historically used throughout the Mediterranean region to treat menstrual cycle disorders, and is still used today as a clinically effective treatment for premenstrual syndrome. As a result, fluorenones are easily oxidized in air. Five flavonoid glycosides (155–159) were isolated during phytochemical investigation of Chrozophora tinctorial. Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. The potent anti-inflammatory flavonoids have been discussed below. J. Econ. Casticin, a flavonoid found in extracts of BV fruits, has demonstrated an ability to inhibit growth of human cancer cells. . Vitex, or chaste tree (Vitex agnus-castus)—celebrated by women in ancient Greek festivals and on holy days as a symbol of marriage, chastity and fertility—gives contemporary women cause for celebration, too: it can safely and effectively relieve the monthly misery of difficult menstrual cycles. Search for more papers by this author. act as febrifuges, and are widely used for this. used medicinal plants. Vitex rotundifolia can be propagated either by seed or by cuttings. Various concentrations of casticin ranging from 0.3 to 10 μM used to treat RAW264.7 cells which were treated with LPS induced inflammation. Be sure to keep the medium moist. Use a sterile planting medium and plant seeds at least ¼ inch deep. Crit, A computer-assisted approach for chemotaxonomic studies – diterpenes in Lamiaceae, Constituents of Vitex rotundifolia L. fil, Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS), Didynamia Angiospermia “Flora des Filipinas Sequn el Sistema sexual de Linneo”, Toward a phylogenetic classification of the Labiatae, Genera of Labiatae: status and classification, Advances in Labiatae Science., Kew: Royal Botanic Gardens, De Plantis in Expeditione Romanzoffiana et in Herbariis Regiis Observatis disserere pergitur, Growing characteristics and propagation of Vitex rotundifolia for development of rehabilitation plant in seaboard area, Korean Journal of Environment and Ecology, Vitex agnus-castus L.: (1) A review of its traditional and modern therapeutic use; (2) Current use from a survey of practitioners, Notes on the systematy and distribution of Malayan phanerogams III, Allelopathic potential of Eupatorium maximiliani Schrad. Ohtsuki T, Shoda T, Kaneko Y and Setoguchi H Development of microsatellite markers for Vitex rotundifolia (verbenaceae), an endangered coastal plant in Lake Biwa, Japan, Appl Plant Sci 2014; 2: 4-7. 181 displayed 5-LOX inhibition at a IC50 value of 0.37 μM while the zileuton had the IC50 value 0.35 μM. Because rotundifuran specifically inhibits cholesterol acyltransferase, the isolated compound is effective in lowering blood cholesterol and can be used in the prevention of cardiovascular disease caused by hypercholesterolemia. The results showed reduced skin inflammation due to sufficient decrease in IL-12 production [215]. 2007). The elaborate THF-containing compound 16 is the active component of a new medicine which has been shown to possess action resisting cancer as well as the AIDS virus <2004CNP1535972>. It does not contain hormones and has an indirect effect on the hormones of the body. Vitex rotundifolia, commonly known as Beach Vitex, is a perennial, invasive species of plant that was introduced to the southeastern United States in the mid- 1980s with hopes that it would stabilize coastal sand dunes.Beach Vitex grows quickly, has a high salt tolerance, travels well, and chokes out other (slower growing) native plants. Epub 2018 Oct 11. BV above ground stems are cut with blades to expose cambial layers. The anti-inflammatory potential of flavonoids accredited with involvement in the inhibition and synthesis of many pro-inflammatory mediators. A tea made from the leaves and stems has been used in the treatment of rheumatism and stomach problems. More Accounts and Images; ARS Germplasm Resources Information Network (VIRO80) CalPhotos (VIRO80) … Asian J Tradit Med. Cochinchinone A (34), 1,3,7-trihydroxy-2,4-diisoprenylxanthone (35), celebixanthone methyl ether (36), cochinchinone L (37), 3-acetoxy-7-geranyloxy-1-hydroxyxanthone(38), 1,3-diacetoxy-7-geranyloxyxanthone (39), 7-acetoxy-3-geranyloxy-1-hydroxy-xanthone (40), 1,7-diacetoxy-3-geranyloxyxanthone (41), 3-geranyloxy-1,7-dihydroxyxanthone (42), and 7-geranyloxy-1,3-dihydroxyxanthone (43), which are isolated from this plant, demonstrate antibacterial potency with a MIC 4.7 μg/mL against Pseudomonas aeruginosa.131,132, Kanzonol compounds and derivatives are well known for their antimicrobial potential. Benefits of Vitex. The described compounds exhibit in vitro activity against metronidazole-sensitive and -resistant T. vaginalis isolates. The fruits of Vitex rotundifolia have been used as a folk medicine for the treatment of headache, cold, migraine, eye pain, female hormonal disorders, asthma, chronic bronchitis and gastrointestinal infections, such as diarrhea and bacterial dysentery. Dragonin A (183) and Dragonin B (184) displayed significant inhibition of superoxide anion induced by fMLP/CB with the IC50 values of 3.1 (183) and 1.3 μM (184), respectively [218]. This compound was one of the 18 responsible for the cytotoxicity against five cultured human tumor cell lines, that is, A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system), and HCT-15 (colon). It is also effective in the cotton pellet induced granuloma model assay, most effective at 10 mg/kg in both assays [210]. It is a muscle relaxant and pain relieving herb. Vitex rotundifolia fractions induce apoptosis in human breast cancer cell line ... Padhi MM, Babu R. A review of the important chemical constituents and medicinal uses of Vitex genus. The plant was first described by Carl von Linnaeus filius in Supplementum Plantarum, published in 1782.. Synonyms. A mature Vitex rotundifolia produces fragrant, blue-purple flowers that are borne in clusters and ultimately yield small purblish-black fruits. While the plant is a seashore obligate, it grows over a wide latitude range. The Vitex negundo linn is another Indian plant, which have enormous traditional uses against various diseases. Vitis rotundifolia, or muscadine, is a grapevine species native to the southeastern and south-central United States. Monte Carlo simulation results (N=5,000) for uncertainty around the risk scores for Vitex rotundifoliaa. Fifteen flavonoids (121–135) isolated from the twigs of Morus alba and evaluated for their anti-inflammatory activities by examining their ability to inhibit LPS-induced NO production in macrophage RAW 264.7 cells. Corresponding author's E-mail: Bip. Plant Produces Flowers Yes [back to top] Flower Characteristics. Although various synthetic strategies towards the fluorenone1c and azafluorenone9g,h were developed, but due to the relatively simple structures, research in this field mainly relies in the biological studies of the isolated natural products. Pharmacological data showed that quinone 9 possessed anti-inflammatory properties, whereas the other two isolated compounds did not <2004CNP1535972>. Vitex agnus-castusL. Representatives of fluorenone natural products. Nirgundi or Five-Leaved Chaste Tree (Vitex negundo) is an evergreen medicinal deciduous shrub. Moldenke: Painfield, New Jersey, Avicenniaceae, Stilbaceae, Chloanthaceae, Synphoremaceae, Nyctanthaceae, and Eriocaulaceae of the World etc, A taxonomic revision of the genus Vitex L, (Verbenaceae)* in Australia Adelaide Botanical Garden, Investigating lag-phase and invasion potential of Vitex rotundifolia: a coastal dune exotic, Aroma constituents in plants and their repellent activities against mosquitoes, Pharmacologically active components of Viticis fructus (Vitex rotundifolia). Subject: Beach Vitex (Vitex rotundifolia): Medicinal Properties, Biology, Invasive Characteristics and Management Options1, (Optional message may have a maximum of 1000 characters.). Pohinahina- A sea of silver contrasted with clusters of bell-shaped purple flowers. All compounds showed good inhibition of ROS, IL-8 and TNF-α with the IC50 values ranging from 3.4 to 38.5 μM. Other descriptions of the leaf fragrance are black pepper, basil, minty, and fir trees or "like being in a forest." The NCSU Arboretum, Amount of calyx fibres in Lamiaceae, relation to calyx structure, phylogeny and ecology, Abietane-type diterpenoids from the fruit of Vitex rotundifolia L-fil, In: A De Candolle Prodromus Systematis Naturalis Regni Vegetabilis, Ecdysteroids from Vitex Species: Distribution and Compilation of Their C-NMR Spectral Data, Effect of Vitex rotundifolia on immediate-type allergic reaction, Constituents of the essential oil of Vitex rotundifolia Linn fil, Koryo, Terupen oyobi Seiyu Kagaku ni kansuru Toronkai Koen Yoshishu, Notes on some interesting species of Verbenaceae from South India.